GLP-1 drugs linked to 15 cases of Wernicke encephalopathy, raising B1 deficiency concerns

A study reports 15 cases of Wernicke encephalopathy, a potentially fatal neurological condition, associated with GLP-1 receptor agonists like Ozempic and Mounjaro. The mechanism is suspected to involve vitamin B1 deficiency, possibly due to rapid weight loss and reduced food intake. This is a small case series, not a causal proof, but it adds to the safety signal for a class of drugs with massive global use, warranting regulatory and clinical attention.